Isolation of 4.5‐Dihydroxyisophthalic Acid, an Inhibitor of Brain Glutamate Decarboxylase, Produced by a Streptomyces Species
Open Access
- 1 January 1978
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 82 (1), 257-259
- https://doi.org/10.1111/j.1432-1033.1978.tb12018.x
Abstract
A potent inhibitor of brain glutamate decarboxylase (L-glutamate 1-carboxy-lyase, EC 4.1.1.15) was isolated from cultures of a Streptomyces species, and its structure was found to be 4,5-dihydroxyisophthalic acid. The metabolite inhibited beef brain glutamate decarboxylase 50% at a concentration of 0.12 μg/ml (0.61 μM). The kinetic analysis indicated that 4,5-dihydroxyisophthalic acid was a competitive inhibitor having a Ki value of 0.18 μM.This publication has 11 references indexed in Scilit:
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