Molecular Cytogenetics of t(12;21)(p13;q22)
- 1 January 1996
- journal article
- review article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 23 (5-6), 459-465
- https://doi.org/10.3109/10428199609054854
Abstract
The translocation t(12;21)(p13;q22) is a frequent nonrandom rearrangement of B-cell lineage childhood acute lymphoblastic leukemia (ALL) which fuses the TEL and AML1 genes, normally localized to 12p13 and 21q22, respectively. The crucial chimeric gene, TEL-AML1, is transcribed from the der(21) and encodes the 336 NH2 aminoacids of TEL fused to the majority of the AML1 protein. The t(12;21) is very often associated with loss of the normal, untranslocated TEL allele. These various aspects are presented here.Keywords
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