Studies on peptides. LIX. Synthesis of the nonatriacontapeptide corresponding to the entire amino acid sequence of porcine adrenocorticotropic hormone.
- 1 January 1976
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 24 (3), 492-499
- https://doi.org/10.1248/cpb.24.492
Abstract
The nonatriacontapeptide corresponding to the newly revised amino acid sequence of porcine ACTH was synthesized by successive condensations of 4 peptide fragments; Z(OCH3)-(15-19)-OH, Z(OCH3)-(11-14)-OH, Z(OCH3)-(5-10)-OH and Z-(1-4)-NHNH2, with H-(20-39)-OC7H7, a synthetic intermediate of porcine corticotropin-like intermediate lobe peptide. The synthetic peptide exhibited the identical Rf value with that of natural porcine ACTH in 2 different solvent systems and its in vivo steroidogentic activity was 148.2 IU/mg.This publication has 2 references indexed in Scilit:
- Studies on peptides. LVIII. Synthesis of Tyr-substance P.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- Die Totalsynthese des β‐Corticotropins (adrenocorticotropes Hormon; ACTH)Helvetica Chimica Acta, 1966