Metabolic Deficiencies in Protozoa Induced by Thalidomide
- 11 January 1963
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 139 (3550), 110-111
- https://doi.org/10.1126/science.139.3550.110
Abstract
Thalidomide inhibits growth of some protozoa. This inhibition was counteracted by nicotinic acid, nicotinamide, nicotinamide adenine dinucleotide, and vitamin K1. The mechanism of toxicity may be an interference of cellular oxidation. A protozoan test system is useful for studying the potential "side actions" of drugs in higher animals and man.Keywords
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