Chromosome findings in effusions from patients with Hodgkin's disease

Abstract
Effusion cells from six patients with advanced Hodgkin's disease were studied. Even though no Hodgkin or Reed‐Sternberg cells could be identified cytologically in five of the six cases, striking chromosome anomalies of a clonal nature, including a number of recurrent marker chromosomes, were demonstrated in all effusions. It is concluded that the effusion cells with abnormal karyotypes were intimately related to the pathogenesis of Hodgkin's disease.