HEMODYNAMIC-CHANGES IN HYPERTENSIVE PATIENTS AT REST AND DURING PHYSICAL EXERCISE BEFORE AND AFTER ACUTE IV ADMINISTRATION OF BUFURALOL-HCL OR PROPRANOLOL

Abstract

The hemodynamic effects of 20 mg Bufuralol-HCl and of 15 mg propranolol given to hypertensives i.v. at rest and under physical exercise conditions were examined. Bufuralol-HCl lowered the diastolic BP [blood pressure] and PR [peripheral resistance] at rest already in the acute experiment, contrary to propranolol. Under physical exercise conditions the diastolic BP is lowered, the PR remains unchanged in spite of reduced CO [cardiac output]. After exclusion of other possible explanations, Bufuralol-HCl may lower the diastolic BP acutely at least partly by inhibition of cerebral .beta.-receptors. A faster and better liquor diffusion could be the reason for these results. The acute BP lowering effect is apparently mediated by the same mechanism as the chronic effect of the other .beta.-receptor blocking drugs.