Parents of High Risk Subjects Defined by Levels of Monoamine Oxidase Activity
- 1 January 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Schizophrenia Bulletin
- Vol. 6 (2), 338-346
- https://doi.org/10.1093/schbul/6.2.338
Abstract
Thirty-seven parents of probands with low platelet monoamine oxidase (MAO) activity levels and 38 parents of high MAO probands were examined for MAO activity, past and present psychopathology, and reported psychopathology in other relatives. Results showed generally positive and significant correlations between parents' and children's MAO levels, significantly greater rates of “high MAO related” disorders in parents and relatives of high MAO probands and of “low MAO related” disorders and symptoms in parents and relatives of low MAO probands. Support for a two-directional monoamine hypothesis of affective disorders is suggested.This publication has 8 references indexed in Scilit:
- Psychiatric Vulnerability, Monoamine Oxidase, and the Average Evoked PotentialArchives of General Psychiatry, 1980
- Platelet Monoamine Oxidase Activity in Schizophrenia: A Review of the DataAmerican Journal of Psychiatry, 1979
- FAMILIAL BIOCHEMICAL AND CLINICAL CORRELATES OF ALCOHOLICS WITH LOW PLATELET MONO-AMINE OXIDASE ACTIVITY1979
- PSYCHOLOGICAL CHARACTERISTICS CORRESPONDING TO LOW VERSUS HIGH PLATELET MONO-AMINE OXIDASE ACTIVITY1979
- A twin study on three enzymes (DBH, COMT, MAO) of catecholamine metabolismPsychopharmacology, 1978
- LOW PLATELET MONOAMINE-OXIDASE ACTIVITY IN HUMAN ALCOHOLICS1977
- Platelet and plasma amine oxidase activity in 680 normals: Sex and age differences and stability over timeBiochemical Medicine, 1976
- The Biochemical High-Risk Paradigm: Behavioral and Familial Correlates of Low Platelet Monoamine Oxidase ActivityScience, 1976