Characterization of a carcinogen‐induced murine B lymphocyte cell line of C3H/eB origin
- 1 July 1977
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 7 (7), 413-417
- https://doi.org/10.1002/eji.1830070702
Abstract
A carcinogen-induced lymphoid tumor, denoted 38C-13, obtained in a T cell-depleted mouse of C3H/eB strain, was adapted to continuous culture in vitro and characterized with respect to its cell surface components. The cells possess IgM class immunoglobulins on their surface but do not secrete it. This membrane IgM is composed of μ and L-chains that are similar in apparent molecular weight to those of an IgM myeloma protein. It is also homogeneous as revealed by isoelectric focusing. The cells possess Fc receptors but lack complement receptors as well as Thy-1 and Ia alloantigens. These characteristics indicate that 38C-13 cells are transformed counterparts of small B lymphocytes at an early stage of differentiation.This publication has 34 references indexed in Scilit:
- Cell surface components of carcinogen‐induced lymphoid tumors in SJL/J miceEuropean Journal of Immunology, 1977
- Synthesis, surface deposition, and secretion of immunoglobulins by abelson virus-transformed lymphosarcoma cell linesCell, 1975
- Immunoglobulin of T lymphoma cells is an integral membrane proteinNature, 1974
- Candidate for immunoglobulin D present on murine B lymphocytesNature, 1974
- Thymus and Bone Marrow Derived Lymphatic Leukaemia in MiceNature, 1973
- CELL SURFACE IMMUNOGLOBULINThe Journal of Experimental Medicine, 1972
- British Optical AstronomyNature, 1972
- IMMUNOGLOBULIN SPOTS ON THE SURFACE OF RABBIT LYMPHOCYTESThe Journal of Experimental Medicine, 1970
- A POPULATION OF LYMPHOCYTES BEARING A MEMBRANE RECEPTOR FOR ANTIGEN-ANTIBODY-COMPLEMENT COMPLEXESThe Journal of Experimental Medicine, 1970
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970