Isolation of inhibitors of adenylate cyclase from dan-shen, the root of Salvia miltiorrhiza.
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 37 (5), 1287-1290
- https://doi.org/10.1248/cpb.37.1287
Abstract
The effect of dan-shen extract, the root of Salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. The EtOAc fraction of the MeOH extract was proved to have significant inhibitory activity. Potent inhibitory principles in the EtOAc fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives.This publication has 6 references indexed in Scilit:
- Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.Proceedings of the National Academy of Sciences, 1981
- Anti-microtubular agents as inhibitors of desensitization to catecholamine stimulation of adenylate cyclase in Ehrlich ascites tumor cellsBiochimica et Biophysica Acta (BBA) - General Subjects, 1979
- Polyphenolic acids of Lithospermum ruderale. II. Carbon-13 nuclear magnetic resonance of lithospermic and rosmarinic acidsThe Journal of Organic Chemistry, 1976
- Lithospermum ruderale: Partial characterization of the principal polyphenol isolated from the rootsPhytochemistry, 1963
- ADENYL CYCLASE .1. DISTRIBUTION, PREPARATION, AND PROPERTIES1962
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951