Synergistic Effect of Somatotropin with -Corticotropin on the Adrenal of Hypophysectomized Rats.
- 1 April 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 97 (4), 828-832
- https://doi.org/10.3181/00379727-97-23892
Abstract
The adrenal gland of hypophysectomized Sprague-Dawley rats showed substantial atrophy 9 days after operation. Histologically-detectable changes in lipid distribution were observed in the zonae glomerulosa, fasciculata and reticularis following hypophysectomy, and a redistributuion of lipid in all 3 zones was effected with [alpha]-ACTH. In addition, a synergism between [alpha]-ACTH and pituitary growth hormone (somatotropin) was demonstrated, the magnitude of the effect being conditioned by the level of exogenous [alpha]-ACTH. These results indicate that somatotropin operates synergistically with ACTH when the 2 hormones are administered in combination to the hypophysectomized rat.Keywords
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