5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline
- 1 January 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (1), 36-39
- https://doi.org/10.1021/jm00187a009
Abstract
Treatment of daunorubicin with methanolic ammonia affords 5-iminodaunorubicin, the 1st quinone-modified analog of daunorubicin or adriamycin. This product retains antileukemic activity in mice [P-388 leukemia cells], is less cardiotoxic by electrocardiographic measurements in rats and is nonmutagenic in Salmonella typhimurium (Ames test).This publication has 8 references indexed in Scilit:
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