Antigenicity of a New Diethylnitrosamine-Induced Transplantable Guinea Pig Hepatoma: Pathology and Formation of Ascites Variant

Abstract

The water-soluble carcinogen, diethylnitrosamine, has been used to induce hepatomas in strain-2 guinea pigs. One of these hepatomas is being transplanted in its original solid form and as an ascites variant. The pathologic and biologic characteristics of this tumor are described and evidence is presented that it is immunogenic in strain-2 guinea pigs. Immunization either intramuscularly or intradermally produced significant protection against growth of a subsequent challenge.