Effects of Catechol Estrogen Infusions upon Gonadotropin and Prolactin Concentrations in Men*

Abstract

To study the effects of catechol estrogens upon gonadotropin secretion, 2-hydroxyestrone (2-OHE1) and 2-hydroxyestradiol (2-OHE2) were administered i.v. to young adult men in a range of doses for 5 days. Blood samples were obtained for plasma LH [luteinizing hormone], FSH and PRL [prolactin] at 20-min intervals for 6 h before and at the end of the infusion period. 2-OHE1 had no effect upon gonadotropins or PRL in doses up to 1.6 mg/day; at 3.2 and 6.6 mg/day, it produced a slight suppression of LH and FSH, with no change in PRL. 2-OHE2 was generally ineffective at 100 .mu.g/day, but doses of 200-800 .mu.g/day suppressed gonadotropins, without changes in PRL. These infusions elevated 2-OHE1 and 2-OHE2 plasma levels to values comparable to those measured in late pregnancy. There were no associated effects upon blood pressure and only minimal changes in urinary catecholamine excretion. No effects that could be interpreted as antiestrogenic were observed. Evidently circulating catechol estrogens behave as weak estrogens in men.