TUMOR-CELL CYTOSTASIS BY MACROPHAGES AND ANTIBODY INVITRO .1. RESOLUTION INTO CONTACT-DEPENDENT AND CONTACT-INDEPENDENT STEPS
- 1 January 1978
- journal article
- research article
- Vol. 120 (5), 1560-1566
Abstract
In a murine system, macrophages, in concert with antibody, suppressed iododeoxyuridine incorporation by tumor cells [line 1 mouse lymphoblastoid cells]. The mechanism of suppression did not involve phagocytosis or lysis. The generation of suppressed tumor cells was resolved into a contact-dependent step and a contact-independent step. The 1st step was 1-hit with respect to macrophages and multi-hit with respect to antibody.This publication has 4 references indexed in Scilit:
- TUMOR-CELL CYTOSTASIS BY MACROPHAGES AND ANTIBODY INVITRO .2. ISOLATION AND CHARACTERIZATION OF SUPPRESSED CELLS1978
- Antibody-mediated suppression of grafted lymphoma. IV. Influence of time of tumor residency in vivo and tumor size upon the effectiveness of suppression by syngeneic antibody.The Journal of Experimental Medicine, 1976
- Inhibition of 125IUdR incorporation by supernatants from macrophage and lymphocyte cultures: A cautionary noteCellular Immunology, 1976
- QUANTITATIVE ASSAY OF LYTIC ACTION OF IMMUNE LYMPHOID CELLS ON 51CR-LABELLED ALLOGENEIC TARGET CELLS IN VITRO - INHIBITION BY ISOANTIBODY AND BY DRUGS1968