Staphylococcus aureus YoeB Homologues Inhibit Translation Initiation
- 15 September 2009
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 191 (18), 5868-5872
- https://doi.org/10.1128/jb.00623-09
Abstract
YoeB is a bacterial toxin encoded by the yefM-yoeB toxin-antitoxin system found in various bacterial genomes. Here, we show that Staphylococcus aureus contains two YoeB homologues, both of which function as ribosome-dependent mRNA interferases to inhibit translation initiation in a manner identical to that of YoeB-ec from Escherichia coli.Keywords
This publication has 24 references indexed in Scilit:
- Invasive Methicillin-Resistant Staphylococcus aureus Infections in the United StatesJAMA, 2007
- Characterization of mRNA Interferases from Mycobacterium tuberculosisJournal of Biological Chemistry, 2006
- Conformational Change in the Catalytic Site of the Ribonuclease YoeB Toxin by YefM AntitoxinMolecular Cell, 2005
- Characterization of ChpBK, an mRNA Interferase from Escherichia coliJournal of Biological Chemistry, 2005
- Insights into the mRNA Cleavage Mechanism by MazF, an mRNA InterferaseJournal of Biological Chemistry, 2005
- Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotesNucleic Acids Research, 2005
- Interference of mRNA Function by Sequence-specific Endoribonuclease PemKJournal of Biological Chemistry, 2004
- Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM‐yoeB toxin‐antitoxin systemMolecular Microbiology, 2004
- Cleavage of the A Site mRNA Codon during Ribosome Pausing Provides a Mechanism for Translational Quality ControlMolecular Cell, 2003
- MazF Cleaves Cellular mRNAs Specifically at ACA to Block Protein Synthesis in Escherichia coliMolecular Cell, 2003