Further Studies on the Developmental Change in Myotrophic Activity of Chicken Serum: Relation between Activity and Transferrin. (developmental change/myotrophic activity/chicken serum/transferrin)

Abstract

The developmental change in trophic activity of chicken serum on chicken myogenic cells in vitro was reexamined and elucidated on the basis of possible changes in serum transferrin (Tf), the myotrophic activity of which depends both on its concentration and on the level of its Fe-saturation. The myotrophic activity was low until the 2nd wk in ovo, then increased rather abruptly to a plateau at about the time of hatching, and then decreased to the adult level. Determination of the concentration and level of Fe-saturation of serum Tf suggested that the change in myotrophic activity was mainly caused by these 2 parameters, though another factor(s) may also be involved.