Effect of selective beta-adrenergic blockade and stimulation on regional myocardial blood flow following acute coronary artery occlusion in the awake dog
- 1 April 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 14 (4), 192-198
- https://doi.org/10.1093/cvr/14.4.192
Abstract
This study was designed to evaluate the effects of alterations of β-receptor activity on intercoronary collateral blood flow after acute coronary artery occlusion in the awake dog. Blood flow following acute circumflex coronary occlusion was measured during: 1) control conditions; 2) selective β1-blockade with practolol; 3) combined β1 and β2 blockade with propranolol; and 4) selective β2 stimulation. Neither practolol nor propranolol significantly altered the volume or distribution of blood flow into the normally perfused or ischaemic myocardial areas, while β2 stimulation increased blood flow to the normally perfused myocardium from 1.13 ± 0.12 to 1.28 ± 0.10 cm3·min−1·g−1 (P 2 stimulation resulted in a 47 ± 12% decrease in collateral flow into the central ischaemic zone (P 2-agonist administration. Thus, although β2 stimulation produced a modest increase in blood flow to normally perfused myocardium, in the setting of acute myocardial ischaemia, β2 stimulation resulted in a significant decrease in intercoronary collateral flow.Keywords
This publication has 7 references indexed in Scilit:
- Effect of nitroglycerin and arterial hypertension on myocardial blood flow following acute coronary artery occlusion in the dog.Circulation, 1978
- Failure of high doses of propranolol to reduce experimental myocardial ischemic damage.Circulation, 1978
- Effects of Propranolol on Regional Myocardial Function, Electrograms, and Blood Flow in Conscious Dogs with Myocardial IschemiaJCI Insight, 1977
- Relationship between blood flow to ischemic regions and extent of myocardial infarction. Serial measurement of blood flow to ischemic regions in dogs.Circulation Research, 1976
- Regional myocardial blood flow during acute myocardial infarction in the conscious dog.Circulation Research, 1976
- The Circulation of the Fetus in UteroCirculation Research, 1967
- Some Determinants of Coronary Collateral Blood Flow in the Open-Chest DogCirculation Research, 1959