Adjuvant Chemotherapy with Doxorubicin (Adriamycin) and 5–Fluorouracil in T3, NX, MO Bladder Cancer Treated with Radiotherapy

Abstract

Radical radiotherapy alone was compared with radical radiotherapy followed by chemotherapy using doxorubicin (Adriamycin) and 5-fluorouracil in a randomized prospective study on 129 patients presenting with T3, NX, MO transitional cell carcinoma of the bladder. Patients (110) were evaluable with a minimum follow-up of 2 yr. The addition of this form of chemotherapy did not appear to influence the survival rate or the proportion of patients free from tumor. It cannot be recommended for routine use in the primary treatment of infiltrating bladder cancer.