Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q.
- 1 April 1996
- journal article
- Vol. 58 (4), 770-6
Abstract
Hereditary mixed polyposis syndrome (HMPS) is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. HMPS appears to be inherited in an autosomal dominant manner. Genetic linkage analysis has been performed on a large family with HMPS. Data did not support linkage to the APC locus or to any of the loci for hereditary nonpolyposis colorectal cancer. Evidence that the HMPS locus lies on chromosome 6q was, however, provided by significant two-point LOD scores for linkage between HMPS and the D6S283 locus. Analysis of recombinants and multipoint linkage analysis suggested that the HMPS locus lies in a 4-cM interval containing the D6S283 locus and flanked by markers D6S468 and D6S301.This publication has 9 references indexed in Scilit:
- The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasiaCell, 1995
- Familial polyposis: recent advancesCritical Reviews in Oncology/Hematology, 1995
- Juvenile polyposisBritish Journal of Surgery, 1995
- The 1993–94 Généthon human genetic linkage mapNature Genetics, 1994
- Two simple procedures for releasing chromatin from routinely fixed cells for fluorescence in situ hybridizationCytogenetic and Genome Research, 1994
- Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouseCell, 1993
- A second-generation linkage map of the human genomeNature, 1992
- Inherited disorders associated with colorectal cancer.1989
- Chromosome 5 allele loss in human colorectal carcinomasNature, 1987