Gene complementing xeroderma pigmentosum group A cells maps to distal human chromosome 9q
- 30 June 1990
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 16 (4), 395-400
- https://doi.org/10.1007/bf01232467
Abstract
Phenotypic complementation of xeroderma pigmentosum group A (XP-A) cells by microcell-mediated transfer of a single rearrangedneo-tagged human chromosome from a human-mouse somatic cell hybrid designated K3SUB1A9-3 was reported previously. Extended growth of this human-mouse hybrid in culture led to deletion of the small arm of the human chromosome, with concomitant loss of complementing ability when introduced into XP-A cells by microcell-mediated chromosome transfer. Cytogenetic analysis of both hybrids suggests that the complementing locus is on chromosome 9q22.2-q34.3, and Southern blot analysis confirms the presence of distal chromosome 9q sequences.This publication has 20 references indexed in Scilit:
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