Cytogenetic toxicity of cyclophosphamide and its metabolites in vitro

1 January 1980

journal article
research article
Published by S. Karger AG in Cytogenetic and Genome Research

Vol. 26 (2-4), 108-116
https://doi.org/10.1159/000131432

Abstract

The effects of cyclophosphamide and three of its known metabolites (nitrogen mustard, acrolein, and nor-nitrogen mustard on chromosome breakage and sister chromatid exchange (SCE) were analyzed in vit

Keywords

This publication has 8 references indexed in Scilit:

Further study of the genetic toxicity of gentian violet
Mutation Research/Genetic Toxicology, 1979
Cytogenetic toxicity of gentian violet and crystal violet on mammalian cells in vitro
Mutation Research/Genetic Toxicology, 1978
CYCLOPHOSPHAMIDE-INDUCED ONCOGENIC TRANSFORMATION, CHROMOSOMAL BREAKAGE, AND SISTER CHROMATID EXCHANGE FOLLOWING MICROSOMAL ACTIVATION
1978
Mutagenic activity of major mammalian metabolites of cyclophosphamide toward several genes ofEscherichia coli
Journal of Toxicology and Environmental Health, 1977
In vitro testing of an indirect mutagen (cyclophosphamide) with human leukocyte cultures: Activation with liver microsomes and use of a dialysis bag
Mutation Research, 1977
Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. II. In vitro test for compounds requiring metabolic activation
Mutation Research, 1976
Genetic effects of cyclophosphamide, ifosf amide and trofosfamide
Mutation Research/Reviews in Genetic Toxicology, 1976
STUDIES ON MECHANISM OF ACTION OF CYTOXAN EVIDENCE OF ACTIVATION IN VIVO AND IN VITRO
1961

Cited by 70 articles