In Vivo Imaging of the Photoreceptor Mosaic in Retinal Dystrophies and Correlations with Visual Function
Open Access
- 1 May 2006
- journal article
- retina
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 47 (5), 2080-2092
- https://doi.org/10.1167/iovs.05-0997
Abstract
Purpose. To relate in vivo microscopic retinal changes to visual function in patients who have various forms of retinal dystrophy. methods. The UC Davis Adaptive Optics (AO) fundus camera was used to acquire in vivo retinal images at the cellular level. Visual function tests consisting of visual fields, multifocal electroretinography (mfERG), and contrast sensitivity were measured in all subjects by using stimuli that were coincident with areas imaged. Five patients with different forms of retinal dystrophy and three control subjects were recruited. Cone densities were quantified for all retinal images. results. In all images of diseased retinas, there were extensive areas of dark space between groups of photoreceptors, where no cone photoreceptors were evident. These irregular features were not seen in healthy retinas, but were apparent in patients with retinal dystrophy. There were significant correlations between functional vision losses and the extent to which these irregularities, quantified by cone density, occurred in retinal images. conclusions. AO fundus imaging is a reliable technique for assessing and quantifying the changes in the photoreceptor layer as disease progresses. Furthermore, this technique can be useful in cases where visual function tests provide borderline or ambiguous results, as it allows visualization of individual photoreceptors.Keywords
This publication has 43 references indexed in Scilit:
- Full‐field ERG, multifocal ERG and multifocal VEP in patients with retinitis pigmentosa and residual central visual fieldsActa Ophthalmologica Scandinavica, 2004
- Correlation between Contrast Sensitivity and Visual Acuity in Retinitis pigmentosa PatientsOphthalmologica, 2002
- Dynamics of the eye’s wave aberrationJournal of the Optical Society of America A, 2001
- Autosomal Dominant Retinitis Pigmentosa Caused by the Threonine-17-Methionine Rhodopsin Mutation: Retinal Histopathology and ImmunocytochemistryExperimental Eye Research, 1994
- The field topography of ERG components in man—I. The photopic luminance responseVision Research, 1992
- Human photoreceptor topographyJournal of Comparative Neurology, 1990
- Quest: A Bayesian adaptive psychometric methodPerception & Psychophysics, 1983
- Contrast sensitivity in retinitis pigmentosa.British Journal of Ophthalmology, 1981
- Cyclic GMP Accumulation Causes Degeneration of Photoreceptor Cells: Simulation of an Inherited DiseaseScience, 1977
- Inherited Retinal Dystrophy: Primary Defect in Pigment Epithelium Determined with Experimental Rat ChimerasScience, 1976