Inherited Retinal Dystrophy: Primary Defect in Pigment Epithelium Determined with Experimental Rat Chimeras
- 21 May 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 192 (4241), 799-801
- https://doi.org/10.1126/science.1265483
Abstract
Chimeric rats were produced by the aggregation of embryos of the pinkeyed, retinal dystrophic RCS strain with those of pigmented, normal rats. In the mosaic eyes, patches of neural retina with abnormal and degenerated photoreceptors were present only opposite patches of nonpigmented, mutant pigment epithelium. This indicates that the retinal dystrophy gene acts in the pigment epithelial cell rather than in the photoreceptor cell.This publication has 16 references indexed in Scilit:
- Role of the pigment epithelium in inherited retinal degeneration analyzed with experimental mouse chimerasExperimental Eye Research, 1976
- Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the ratExperimental Eye Research, 1975
- Chimaera mouse study shows absence of disease in genetically dystrophic muscleNature, 1974
- PHOTORECEPTOR-PIGMENT EPITHELIAL CELL RELATIONSHIPS IN RATS WITH INHERITED RETINAL DEGENERATIONThe Journal of cell biology, 1972
- Relationship of genotype and degree of chimerism in coat color to sex ratios and gametogenesis in chimeric miceJournal of Experimental Zoology, 1971
- THE ROLE OF THE PIGMENT EPITHELIUM IN THE ETIOLOGY OF INHERITED RETINAL DYSTROPHY IN THE RATThe Journal of cell biology, 1971
- Patchy Retinal Degeneration in Tetraparental MiceNature, 1971
- PARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESSThe Journal of cell biology, 1969
- Pink-eyed dilution (p) gene in rodents: Increased pigmentation in tissue cultureDevelopmental Biology, 1965
- INHERITED RETINAL DYSTROPHY IN THE RATThe Journal of cell biology, 1962