Evidence for a new HLA class II determinant present on cells from HLA‐DR1 and/or ‐DR4 individuals
- 1 February 1985
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 25 (2), 96-102
- https://doi.org/10.1111/j.1399-0039.1985.tb00421.x
Abstract
Evidence for a new HLA class II specificity is presented. It is recognized by LE serum, which reacts with most DR1 and/or DR4 individuals (r = 0.86). Its frequency in the French population is 0.33. Absorption-elution experiments showed that the serum reactivity was not due to a mixture of anti-DR1 and anti-DR4 antibodies, but to a single antibody population which could be absorbed on and eluted from both DR1(+) or DR4(+) cells. LE specificity seemed to be expressed on DR but not on DQ molecules since the serum reacted with and could be absorbed by DR+,DQw- cells; it did not react with a DR-,DQw+ mutant cell, but did react with the DR+,DQw+ parental cell. The relationship between LE specificity and MC1 and Te23 specificities remains to be determined.Keywords
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