Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine
- 1 June 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 24 (6), 759-760
- https://doi.org/10.1021/jm00138a024
Abstract
(Z)-5-(2-Bromovinyl)uracil was obtained by photoisomerization of the E isomer; (E)-5-(2-bromovinyl)-2''-deoxyuridine gave the required Z isomer. (Z)-5-(2-Bromovinyl)-2''-deoxyuridine is much less active against herpes simplex virus type 1 (HSV-1) and somewhat less active against herpes simplex virus type 2 than is the E isomer. Both isomers show similar activity against vaccinia virus. The highly potent and selective activity of (E)-5-(2-bromovinyl)-2''-deoxyuridine against HSV-1 is due to its E configuration.This publication has 2 references indexed in Scilit:
- Incorporation of 5-substituted uracil derivatives into nucleic acids—IIITetrahedron, 1976
- PALLADIUM CATALYST FOR PARTIAL REDUCTION OF ACETYLENESOrganic Syntheses, 1966