Ionic mechanism of inotropic effect of prostaglandin E1 on frog atrial muscle
- 1 October 1976
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 366 (1), 79-81
- https://doi.org/10.1007/bf02486564
Abstract
Prostaglandin E1 increases the amplitude and duration of cardiac action potential and exerts a positive inotropic effect on the frog heart. In voltage-clamp experiments, prostaglandin E1 increases both, the slow inward current and the delayed outward as well as the two components of the heart contraction. These results imply that calcium influx and the release of intracellular calcium are involved in the inotropic action of prostaglandin E1.This publication has 14 references indexed in Scilit:
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