Isolated Retinas Synthesize Visual Pigments from Retinol Congeners Delivered by Liposomes
- 23 June 1978
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4348), 1393-1395
- https://doi.org/10.1126/science.307275
Abstract
Isolated vertebrate retinas bathed in circulating Ringer solution cannot regenerate all of their bleached visual pigments. When dioleoyl-lecithin vesicles containing certain retinol congeners are added to the Ringer solution, such retinas begin to regenerate pigment immediately. The visual pigment of a bleached perfused retina can now be restored fully, making the isolated retina an independent unit for study. Loposomes can protect oxygen-sensitive, lipid-soluble substances and deliver them to living cells.Keywords
This publication has 12 references indexed in Scilit:
- Rhodopsin regeneration in rod outer segments: Utilization of 11-cis retinal and retinolExperimental Eye Research, 1977
- Liposome-Cell Interaction: Transfer and Intracellular Release of a Trapped Fluorescent MarkerScience, 1977
- Visual Adaptation: Effects of Externally Applied Retinal on the Light-Adapted, Isolated Skate RetinaScience, 1976
- Topology of the Outer Segment Membranes of Retinal Rods and Cones Revealed by a Fluorescent ProbeScience, 1974
- Dark Current and Photocurrent in Retinal RodsBiophysical Journal, 1970
- Delayed off-responses recorded from the isolated frog retinaVision Research, 1968
- Light and Dark Adaptation in the Isolated Rat RetinaNature, 1967
- Respiratory and Electrical Responses to Light Stimulation in the Retina of the FrogScience, 1965
- CIS-TRANS ISOMERS OF VITAMIN A AND RETINENE IN THE RHODOPSIN SYSTEMThe Journal of general physiology, 1952
- THE REGENERATION OF VISUAL PURPLE IN THE LIVING ANIMALThe Journal of general physiology, 1942