Kinetics of buccal absorption of some carboxylic acids and the correlation of the rate constants and n-heptane:aqueous phase partition coefficients

Abstract

A simple model for the buccal absorption of some carboxylic acids is proposed. This model has been used, in conjunction with an analogue computer, to determine the rate constants of buccal absorption of ten acids from solutions of pH 4·0 using a single subject. These rate constants gave a positive correlation with the logarithms of previously determined n-neptane:0·1 N hydrochloric acid partition coefficients (correlation coefficient 0·89).