A tris(2,2′-bipyridine)ruthenium(ii) derivative tethered to a cis-PtCl2(amine)2moiety: syntheses, spectroscopic properties, and visible-light-induced scission of DNA
- 18 April 2006
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Dalton Transactions
- No. 27,p. 3300-3305
- https://doi.org/10.1039/b600165c
Abstract
A tris(2,2′-bipyridine)ruthenium(II) derivative having two N-(3-ammoniopropyl)carbamoyl pendant units has been prepared and reacted with cis-PtCl2(DMSO)2 (DMSO = dimethyl sulfoxide) to give a heteronuclear Ru(II)Pt(II) dimer having a cis-Pt(II)Cl2(aliphatic amine)2 unit, [Ru(bpy)2(µ-bridge)PtCl2](PF6)2 (bpy = 2,2′-bipyridine, bridge = 4,4′-bis(N-(3-aminopropyl)carbamoyl)-2,2′-bipyridine). The ESI-TOF mass spectrum of the Ru(II)Pt(II) dimer shows a set of signals corresponding to {[Ru(bpy)2(µ-bridge)PtCl2](PF6)}+ (m/z 1181.1). The MLCT (metal-to-ligand charge transfer) luminescence intensity is enhanced upon the platination of two amine units, presumably due to the formation of a relatively rigid metallocycle. More interestingly, the luminescence intensity is further enhanced by the complexation of the Ru(II)Pt(II) dimer with either 5′-GMP (guanosine 5′-monophosphate disodium salt) or calf thymus DNA. Visible-light-induced scission of supercoiled pBR322 DNA is found to be efficiently enhanced in the presence of the title Ru(II)Pt(II) dimer.Keywords
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