α-Methoxyketone synthesis via ketone homologation: ZrCl4-mediated hydroxy sulfone rearrangements
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 19,p. 2289-2290
- https://doi.org/10.1039/c39940002289
Abstract
The adducts between ketones and the anion derived from [(methoxymethyl)sulfonyl]benzene undergo efficient, regioselective rearrangement to give α-methoxyketones when treated with ZrCl4 and HfCl4; this new procedure allows the sulfone-mediated homologation methodology to be applied to monocyclic and acyclic ketones.Keywords
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