Irreversible Gene Repression Model for Control of Development
- 14 July 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 201 (4351), 120-130
- https://doi.org/10.1126/science.351805
Abstract
As the pluripotent cells of early embryos differentiate, each progressively loses the potency to develop into several phenotypes. Ultimately, each cell becomes irreversibly restricted to the expression of a single phenotype. Although in many instances details regarding those restriction events are well known, there is little information concerning the nature of the gene transcription changes involved. A model that accounts for the diminution of developmental potential as resulting from progressive, irreversible repression of previously active genes is presented. A scheme of progressive gene repression, rather than selective gene activation, is most consistent with observations from experimental embryology as well as from more recent biochemical experimentation.This publication has 77 references indexed in Scilit:
- Comparison of the base-sequence complexities of polysomal and nuclear RNAs in growing Friend erythroleukemia cellsBiochemistry, 1977
- Conservation of cytoplasmic poly(A)-containing RNA in mouse and ratNature, 1975
- Myoglobin synthesis in cell cultures of red and white muscleJournal of Cellular Physiology, 1973
- Biogenesis of mRNA: Genetic Regulation in Mammalian CellsScience, 1973
- Effects of the nicotinamide-sensitive teratogen 3-acetylpyridine on chick limb cells in cultureExperimental Cell Research, 1970
- A phase-shift model for the spatial and temporal organization of developing systemsJournal of Theoretical Biology, 1969
- Positional information and the spatial pattern of cellular differentiationJournal of Theoretical Biology, 1969
- The stabilization of cartilage properties in the cartilage‐forming mesenchyme of the embryonic chick limbJournal of Experimental Zoology, 1969
- Titration of the gene sites on DNA by DNA-RNA hybridizationJournal of Molecular Biology, 1968
- Studies on germ cells. I. The history of the germ cells in insects with special reference to the Keimbahn‐determinants. II. The origin and significance of the Keimbahn‐determinants in animalsJournal of Morphology, 1914