Inhibition of Lipid Synthesis by Epinephrine in Isolated Rat Liver Cells

Abstract

Epinephrine produced a uniform inhibition of the incorporation of ¹⁴C-acetate into all classes of cellular lipids in isolated rat liver cells. The reduced label in cellular lipids did not result from an increased release of labeled lipids into the incubation medium or from an enhanced degradation of labeled lipids. Cyclic 3',5' AMP affected acetate incorporation in a manner similar to epinephrine. These observations suggest that epinephrine inhibits an early step in the biosynthetic pathway of lipids, and that the action of epinephrine may be mediated by stimulation of adenyl cyclase activity. 1 This work was supported by grants from the United States Public Health Service (HE09506 and AM5136)