Increase of Natural Killer Activity of Mouse Lymphocytes Followingin vitroandin VivoTreatment with Lithium
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Immunopharmacology and Immunotoxicology
- Vol. 10 (1), 79-91
- https://doi.org/10.3109/08923978809014403
Abstract
The in vivo and in vitro influence of lithium lactate on mouse natural killer activity was investigated. In vitro exposure of effector-target mixture to graded concentration of lithium did not substantially modify the natural killer activity of mouse splenocytes, untreated or pretreated with cyclophosphamide. However in vitro treatment of effector splenocytes increased the freguency of NK-percursor cells. The in vivo treatment with lithium lactate greatly increased the natural killer activity in intact mice, whereas it did not improve this cytotoxic function in host immunodepressed by cyclophosphamide. These data suggest that lithium salts produce a modulation of natural killer activity of mouse spleen cells, probably through a mechanism involving the increase of the number of NK-precursors in hosts not subjected to cytotoxic chemotherapy.This publication has 22 references indexed in Scilit:
- Specificity of lithium (Li+) to enhance the production of colony stimulating factor (GM-CSF) from mitogen-stimulated lymphocytes in vitroCellular Immunology, 1984
- Inhibition of Human NK Cell Cytotoxicity by Induction of Cyclic AMP Depends on Impaired Target Cell RecognitionScandinavian Journal of Immunology, 1983
- HYPOTHESIS ON THE DEVELOPMENT OF NATURAL KILLER CELLS AND THEIR RELATIONSHIP TO T CELLSPublished by Elsevier ,1982
- Radiation Resistance in Mice Increased Following Chronic Application of Li2Co3Acta Radiologica: Oncology, 1982
- The Effect of Lithium on Murine Hematopoiesis in a Liquid Culture SystemNew England Journal of Medicine, 1980
- The effect of immunopharmacological agents on mouse natural cell-mediated cytotoxicity and on its augmentation by poly I:CImmunopharmacology, 1979
- Natural Killer Cells: Characteristics and Regulation of ActivityImmunological Reviews, 1979
- Lithium and LeukocytosisAnnals of Internal Medicine, 1976
- Leukocytosis During Lithium TreatmentAmerican Journal of Psychiatry, 1971