Regional Distribution and Production Rate of 3‐Methoxy‐4‐Hydroxyphenylethyleneglycol Sulphate (MHPG‐SO4) in Rat Brain
- 1 January 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 36 (1), 286-289
- https://doi.org/10.1111/j.1471-4159.1981.tb02405.x
Abstract
The levels of noradrenaline (NA) and 3-methoxy-4-hydroxyphen-ylethyleneglycol sulphate (MHPG-SO4) in 15 brain regions showed a parallel distribution in male Wistar rats. The differences in regional distribution of MHPG-SO4 were similar to those in the rate of NA turnover reported by other investigators. The accumulation rates of MHPG-SO4 during 45 and 90 min after probenecid injection significantly correlated to the steady state levels of MHPG-SO4 in nine regions studied. With the results, the regional levels of MHPG-SO, either in untreated or in probenecid-treated rats, are considered to be a useful index of NA turnover.Keywords
This publication has 24 references indexed in Scilit:
- Effect of probenecid on mouse brain tyrosine hydroxylase activity and catecholaminesNeuropharmacology, 1980
- Changes in regional brain levels of tryptophan, 5‐hydroxytryptamine, 5‐hydroxyindoleacetic acid, doparnine and noradrenaline after pinealectomy in the ratJournal of Neurochemistry, 1979
- Turnover rates of serotonin, norepinephrine and dopamine concurrently measured in seven rat brain regionsProgress in Neuro-Psychopharmacology, 1978
- A SENSITIVE FLUOROMETRIC METHOD FOR THE ESTIMATION OF 3,4‐DIHYDROXYPHENYLETHYLENE GLYCOL SULPHATE IN BRAIN TISSUEJournal of Neurochemistry, 1978
- CORRELATION BETWEEN TYROSINE HYDROXYLASE ACTIVITY AND CATECHOLAMINE CONCENTRATION OR TURNOVER IN BRAIN REGIONS1Journal of Neurochemistry, 1977
- Central noradrenergic activity and the formation of glycol sulfate metabolites of brain norepinephrineLife Sciences, 1976
- ESTIMATION OF NORADRENALINE AND ITS MAJOR METABOLITES SYNTHESIZED FROM [3H]TYROSINE IN THE RAT BRAINJournal of Neurochemistry, 1976
- Effect of stress on sulfated glycol metabolites of brain norepinephrineLife Sciences, 1975
- Brain RNA and Hypophysectomy; A Topographical StudyNeuroendocrinology, 1972
- GLYCOL SULPHATE ESTER FORMATION FROM [14C]NORADRENALINE IN BRAIN AND THE INFLUENCE OF A COMT INHIBITORJournal of Neurochemistry, 1971