Possible Linkage between the Major Histocompatibility Complex and the Immune Response to Factor VIII in Classic Haemophilia
- 1 November 1977
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 33 (5), 270-272
- https://doi.org/10.1111/j.1423-0410.1977.tb04473.x
Abstract
The pattern of HLA segregation was analyzed in 10 sibships of hemophilia A patients, each of which included 1 or 2 hemophilic brothers with an antibody to factor VIII. The observed HLA distribution is suggestive of a linkage between the major histocompatibility complex and a gene responsible for immune response to isologous factor VIII.This publication has 8 references indexed in Scilit:
- Antibodies to factor VIII. V. Patterns of immune response to factor VIII in hemophilia ABlood, 1976
- Factor-VIII-related antigen: multiple molecular forms in human plasma.Proceedings of the National Academy of Sciences, 1975
- Cyanogen bromide and tryptic fragments of normal and haemophilic factor VIIIThrombosis Research, 1975
- Willebrand Factor and Ristocetin II. RELATIONSHIP BETWEEN WILLEBRAND FACTOR, WILLEBRAND ANTIGEN AND FACTOR‐VIII ACTIVITYBritish Journal of Haematology, 1974
- A Mixed Lymphocyte Culture Micro‐Technique and its Application in Different Family and Unrelated CombinationsTissue Antigens, 1974
- Préparation et congélation de lymphocytes et de plaquettes d'origine humaine pour la recherche d'anticorpsRevue Française de Transfusion Et Immuno-Hématologie, 1970
- RAPID PREPARATION OF LYMPHOCYTES FOR TISSUE-TYPINGThe Lancet, 1969
- SEROTYPING FOR HOMOTRANSPLANTATION XVIII. REFINEMENT OF MICRODROPLET LYMPHOCYTE CYTOTOXICITY TESTTransplantation, 1968