An open clinical trial of L-dopa and carbidopa in adults with minimal brain dysfunction

Abstract

Minimal brain dysfunction [MBD] has long been considered a childhood disorder. Recent research suggests than in some it persists into adult life and that at least one form is a consequence of reduced activity of dopaminergic systems in the brain. To test this hypothesis, 3 adults with presumptive MBD were given L-dopa plus carbidopa. Although overall this combination was less effective than stimulant medication, all the patients showed an initial response and in 1 patient L-dopa seemed to potentiate the effect of methylphenidate. Various dopamine agonists have different effects and the possible potentiation effect is consistent with a dopaminergic hypothesis.