Molecular Genetics of Allergic Diseases
- 1 April 2000
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 18 (1), 347-366
- https://doi.org/10.1146/annurev.immunol.18.1.347
Abstract
Allergic diseases affect approximately one third of the general population. This class of disease, characterized by elevated serum IgE levels and hypersensitivity to normally innocuous antigen, can manifest in practically any mucosal tissue or as a systemic response. A few examples of serious allergic diseases include asthma, dermatitis, bee sting allergy, food allergy, conjunctivitis, and severe systemic anaphylaxis. Taken together, allergic diseases constitute one of the major problems of modern day medicine. A considerable portion of the healthcare budget is expended in the treatment of allergic disease, and morbidity rates of inner city asthmatics are rising steadily. Due to the enormity of the problem, there has been a worldwide effort to identify factors that contribute to the etiology of allergic diseases. Epidemiologic studies of multigeneration families and large numbers of twins clearly indicate a strong genetic component to atopic diseases. At least two independently segregating diseasesusceptibility genes are thought to come together with environmental factors to result in allergic inflammation in a particular tissue. On the basis of the strong genetic studies, multiple groups have attempted to identify disease-susceptibility genes via either a candidate gene approach or by genome-wide scans. Both of these approaches have implicated multiple regions in the human and mouse genomes, which are currently being evaluated as harboring putative atopy genes.Keywords
This publication has 56 references indexed in Scilit:
- Chromosome 11q13 and atopic asthmaClinical Genetics, 1999
- Linkage of house dust mite allergy with the HLA regionAnnals of Allergy, Asthma & Immunology, 1999
- Genetic regulation of Dermatophagoides pteronyssinus–specific IgE responsiveness: A genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibsJournal of Allergy and Clinical Immunology, 1998
- Evidence for Linkage between the Development of Asthma in Childhood and the T-Cell Receptor β Chain Gene in JapaneseGenomics, 1998
- Polymorphism in transporter antigen peptides gene (TAP1) associated with atopy in Tunisians☆☆☆★★★Journal of Allergy and Clinical Immunology, 1997
- Familial atopy in Australian pedigrees: adventitious linkage to chromosome 8 is not confirmed nor is there evidence of linkage to the high affinity IgE receptorClinical and Experimental Allergy, 1994
- A 2.8 Mb YAC contig in 11q12 – q13 localizes candidate genes for atopy: FcɛRIβ and CD20Human Molecular Genetics, 1994
- Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6pClinical and Experimental Allergy, 1992
- Maternal inheritance of atopic IgE responsiveness on chromosome 11 qThe Lancet, 1992
- Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholineJournal of Allergy and Clinical Immunology, 1992