Persistent Antibody Response to the HIV-1 Negative Regulatory Factor in HIV-1 Infected Seronegative Persons
- 26 January 1989
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 320 (4), 251-252
- https://doi.org/10.1056/nejm198901263200415
Abstract
To the Editor: The silent period that follows exposure to HIV type 1 (HIV-1) and precedes seroconversion remains a problem in the screening of the blood supply.1 Besides the virion structural proteins gag, pol, and env, the HIV-1 provirus also codes for nonstructural proteins that have a regulatory role in the synthesis of infectious virions. Among these genes, the negative regulatory factor (nef/F/3'ORF) is involved in the down-regulation of virus replication2 3 4 and may therefore participate in the establishment and maintenance of latency in infected cells.We have investigated the antibody response to nef in 17 asymptomatic HIV-seronegative persons at . . .Keywords
This publication has 5 references indexed in Scilit:
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- IDENTIFICATION OF HIV-INFECTED SERONEGATIVE INDIVIDUALS BY A DIRECT DIAGNOSTIC TEST BASED ON HYBRIDISATION TO AMPLIFIED VIRAL DNAThe Lancet, 1988
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- HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene productNature, 1987
- Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication.Proceedings of the National Academy of Sciences, 1987