Aldosterone-Induced Sodium Appetite: Dose-Response and Specificity

Abstract

Rats were injected subcutaneously with 0, 30, 60 or 120 [mu]g of d-aldosterone acetate over a 24-hr. period and then allowed to drink a 0.15[image] NaCl solution for 30 min. NaCl intake increased linearly with increasing doses of aldosterone. In a 2nd experiment rats were injected with 0 or 120 [mu]g doses of d-aldosterone acetate and were given 0.15[image] solutions of either NaHC3, KC1, CaCl2, MgCl2 or dextrose to drink. The 120 [mu] g dose produced an increase in the intake of the NaHCO3 solution but had no effect on the intake of the other solutions.