Gamma-vinyl-GABA: A single-blind trial in patients with epilepsy
- 1 July 1983
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 68 (1), 34-39
- https://doi.org/10.1111/j.1600-0404.1983.tb04812.x
Abstract
The anti-epileptic effect of .gamma.-vinyl-GABA (GVG) was studied using a placebo-controlled, single-blind design in 15 patients with therapy-resistant epilepsy, the majority experiencing complex partial seizures. GVG was added to concomitant treatment, which was kept at constant serum levels. Following administration of 1, 2 and 3 g/day, significant reductions in seizure frequency were observed. A poor correlation was found between GVG serum levels and clinical effect. Only mild and transient side-effects were observed.Keywords
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