The Effects of Chemical and Physical Agents on Filariform Larvae of Ancylostoma Braziliense

Abstract

Summary A study in vitro was performed, testing 183 compounds against the filariform larvae of Ancylostoma braziliense. As previous workers had found, the larvae are resistant to many commonly used parasiticides. Among the organic phosphates, Co-ral (O,O-diethyl O-(3-chloro-4-methyl-7-coumarinyl) phosphorothioate) and malathion had activity which might be of practical value in the treatment of human infections and for application to contaminated soil. Dilan among the chlorinated hydrocarbons, chlorpromazine among the phenothiazines and Vapam® among the nematocides showed similar activity. The importance of spontaneous cure of creeping eruption in the evaluation of drug therapy is discussed.