A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse
- 19 January 1990
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 247 (4940), 322-324
- https://doi.org/10.1126/science.2296722
Abstract
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.This publication has 16 references indexed in Scilit:
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