Incidence of Fungal Infection in Positive Donor Rim Cultures after Corneal Transplantation
- 9 February 2021
- journal article
- research article
- Published by Taylor & Francis in Ocular Immunology and Inflammation
- Vol. 30 (4), 864-868
- https://doi.org/10.1080/09273948.2020.1841806
Abstract
To determine the clinical outcomes of corneal transplant patients that had positive rim cultures for fungi. Retrospective study. Of 1276 rim cultures obtained between 2009 and 2019, 16 were positive for fungus (incidence of 1.25%). Clinical data were available for 12 patients. Candida and Cladosporium species were the most common organisms. Recipient ages ranged from 51 to 86 (median age 69 years; 9 males, 7 females). The most common surgery was Endothelial Keratoplasty (n = 8). There were no instances of fungal keratitis or endophthalmitis. Three patients were treated with prophylactic antimycotics. One patient developed bacterial keratitis. One patient had a varicella zoster virus reactivation without corneal involvement. This study adds to the growing data on the low rate of fungal keratitis and endophthalmitis after a corneal transplant, even in the case of positive rim cultures. This study also suggests that positive rim cultures do not advance the risk of postoperative fungal infection in the recipient.Keywords
Funding Information
- Eye Bank Association of America
This publication has 23 references indexed in Scilit:
- Report of the Eye Bank Association of America Medical Advisory Board Subcommittee on Fungal Infection After Corneal TransplantationCornea, 2013
- Risk Factors for Donor Cornea ContaminationCornea, 2013
- Microbial Keratitis After Descemet Stripping Automated Endothelial KeratoplastyEye & Contact Lens: Science & Clinical Practice, 2011
- Late-onset Candida Keratitis after Descemet Stripping Automated Endothelial Keratoplasty: Clinical and Confocal Microscopic ReportEuropean Journal of Ophthalmology, 2011
- Candida glabrata endophthalmitis following penetrating keratoplasty in a patient with negative donor rim cultureBMC Ophthalmology, 2010
- Donor-Related Candida Keratitis After Descemet Stripping Automated Endothelial KeratoplastyCornea, 2009
- Candida Keratitis After Descemet Stripping and Automated Endothelial KeratoplastyCornea, 2009
- Candida albicans Interface Infection After Deep Anterior Lamellar KeratoplastyCornea, 2007
- Efficacy and Safety of Voriconazole as an Additive in Optisol GSCornea, 2007
- Eye-banking risk factors for fungal endophthalmitis compared with bacterial endophthalmitis after corneal transplantationAmerican Journal of Ophthalmology, 2005