SPECIFIC SEROLOGICAL MARKERS IN THE DIAGNOSIS OF FULMINANT HEPATIC FAILURE ASSOCIATED WITH HALOTHANE ANAESTHESIA
- 1 January 1983
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 55 (1), 15-19
- https://doi.org/10.1093/bja/55.1.15
Abstract
The etiology of massive liver-cell necrosis which developed in 16 patients following halothane anesthesia was investigated by means of new serological techniques. In 8 patients a specific halothane-related antibody was found, indicating that these patients were sensitized to halothane-altered liver-cell membrane components. In 4 patients, hepatitis A viral infection was responsible and among the remainder one was receiving anti-tuberculous drugs and one had received a blood transfusion, thus raising the possibility of a non-A non-B viral infection. There were no biochemical or histological differences between patients in the 3 groups.This publication has 4 references indexed in Scilit:
- Oxidative metabolism of halothane in the production of altered hepatocyte membrane antigens in acute halothane-induced hepatic necrosisGut, 1981
- Antibodies to the Surface of Halothane-Altered Rabbit Hepatocytes in Patients with Severe Halothane-Associated HepatitisNew England Journal of Medicine, 1980
- Hepatitis type A, B, and non-A non-B in fulminant hepatitis.Gut, 1980
- ISONIAZID-RIFAMPIN FULMINANT HEPATITIS - POSSIBLE CONSEQUENCE OF ENHANCEMENT OF ISONIAZID HEPATOTOXICITY BY ENZYME-INDUCTION1977