Comparison of Leukocyte Response to ACTH and Bacterial Pyrogen.

Abstract

Summary The leukocyte response to bacterial pyrogen is superficially similar to that produced by ACTH. However, removal of the adrenals substantially modifies the response to ACTH in the dog, but is without effect on pyrogen induced leukocyte responses. It is concluded that pyrogen produces its characteristic changes in the W.B.C. count by mechanisms other than pituitary-adrenal discharge.