Resistance to Erythropoietin

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Abstract
The main function of red cells is to transport oxygen from the lungs to the peripheral tissues. Erythropoietin controls red-cell production by stimulating the differentiation of erythroid progenitor cells in the bone marrow. The hormone originates mainly in specialized interstitial renal cells, which respond to a decrease in oxygen delivery by increasing their production of erythropoietin. The purification of erythropoietin from the urine of patients with aplastic anemia by Miyake et al.1 permitted cloning of the erythropoietin gene in 1985. The commercial production of recombinant erythropoietin soon followed, opening the way to the first clinical trials of a hematopoietic growth . . .