Transformation of Lymphocytes From Patients With Multiple Sclerosis
- 1 July 1970
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 23 (1), 32-40
- https://doi.org/10.1001/archneur.1970.00480250036006
Abstract
PEARMIN et al1in 1963 were the first to demonstrate antigen stimulated mitosis of specifically sensitized leukocytes in tissue culture. These stimulated cells had the same blast-like morphologic appearance as the cells previously described by Hungerford et al2and Nowell3as "transformed" in response to phytohemagglutinin (PHA), which initiates this response independently of previous immunologic sensitization. Since then, a specific transformation response has been demonstrated to many different antigens and has been found to correlate better with delayed hypersensitivity than with circulating antibody.4 The idea was quickly proposed that the transformation response could be used as a test for specific sensitization in diseases thought to be of autoimmune etiology.5Several authors6-14have now reported transformation studies of leukocytes from patients with multiple sclerosis. The results of those studies in which morphological methods were used to evaluate the transformation response to neural antigens haveKeywords
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