Genetic Defect in Biosynthesis of the Precursor Form of the Fourth Component of Complement
- 6 January 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4324), 69-70
- https://doi.org/10.1126/science.199.4324.69
Abstract
Under cell-free conditions, liver polysomes from guinea pigs genetically deficient in the fourth component of complement (C4) did not synthesize pro-C4 (the precursor of C4), but did synthesize nascent C4 polypeptides which remained polysome bound. The defect was specific for pro-C4 synthesis since the amounts of total protein and albumin synthesis and release from C4-deficient polysomes were similar to that in normal guinea pig liver polysomes.This publication has 10 references indexed in Scilit:
- Molecular Size and Subunit Structure of the Fourth Component of Guinea Pig ComplementThe Journal of Immunology, 1977
- Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4).Proceedings of the National Academy of Sciences, 1977
- Linkage of the gene controlling the synthesis of the fourth component of complement to the major histocompatibility complex of the guinea pigImmunogenetics, 1976
- FOURTH COMPONENT OF HUMAN COMPLEMENT: DESCRIPTION OF A THREE POLYPEPTIDE CHAIN STRUCTUREThe Journal of Experimental Medicine, 1974
- The Molecular Basis of ThalassemiCRC Critical Reviews in Biochemistry, 1974
- Induction of β-Globin Synthesis in the β-Thalassaemia of FerraraNature New Biology, 1972
- Biosynthesis of C4 (Fourth Component of Complement) by Hybrids of C4-Deficient Guinea Pig Cells and HeLa CellsScience, 1972
- IN VITRO STUDIES OF COMPLEMENT FUNCTION IN SERA OF C4-DEFICIENT GUINEA PIGSThe Journal of Experimental Medicine, 1971
- IN VIVO STUDIES IN C4-DEFICIENT GUINEA PIGSThe Journal of Experimental Medicine, 1971
- Genetically Controlled Total Deficiency of the Fourth Component of Complement in the Guinea PigScience, 1970