CELLULAR IMMUNOABSORBENTS IN TRANSPLANTATION IMMUNITY
Open Access
- 1 April 1972
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 135 (4), 972-984
- https://doi.org/10.1084/jem.135.4.972
Abstract
Mouse lymphoid cells, sensitized against tumor allografts, can be deprived of the immunoreactive cells by in vitro absorption with specific fibroblast monolayers. Populations of lymphocytes so depleted are less effective in retarding tumor growth in vivo and in lysing tumor cells in vitro. Moreover, the adsorbed immunoreactive cells can be recovered specifically and are subsequently efficient in inhibiting tumor growth in vivo and in killing tumor cells in vitro. Further evidence is presented for the suggestion that the destruction of target cells in vitro by sensitized lymphoid cells is truly representative of the mode of destruction of grafted cells in vivo.Keywords
This publication has 17 references indexed in Scilit:
- IN VITRO INDUCTION OF A HETEROGRAFT REACTIONTransplantation, 1971
- Interaction of immune lymphocytes with the mixtures of target cells possessing selected specificities of the H-2 immunizing allele.1971
- Kinetic analysis of a graft reaction induced in cell culture.1969
- CELL SEPARATION ON ANTIGEN-COATED COLUMNSThe Journal of Experimental Medicine, 1969
- QUANTITATIVE ASSAY OF LYTIC ACTION OF IMMUNE LYMPHOID CELLS ON 51CR-LABELLED ALLOGENEIC TARGET CELLS IN VITRO - INHIBITION BY ISOANTIBODY AND BY DRUGS1968
- QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITROThe Journal of Experimental Medicine, 1965
- QUANTITATIVE TITRATIONS OF MOUSE H-2 ANTIBODIES USING Cr51-LABELLED TARGET CELLSTransplantation, 1965
- IMMUNE MECHANISMS IN HOMOTRANSPLANTATION .2. QUANTITATIVE ASSAY OF IMMUNOLOGIC ACTIVITY OF LYMPHOID CELLS STIMULATED BY TUMOR HOMOGRAFTS1961
- Cellular Antibodies in Kidney HomotransplantationThe Journal of Immunology, 1960
- STUDIES ON THE IMMUNOLOGICAL RESPONSE TO FOREIGN TUMOR TRANSPLANTS IN THE MOUSEThe Journal of Experimental Medicine, 1955