Disulfiram Enhances Pharmacological Activity of Barbital and Impairs Its Urinary Elimination
- 11 August 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 201 (4355), 543-544
- https://doi.org/10.1126/science.663674
Abstract
Disulfiram or diethyldithiocarbamate significantly enhanced the sleeping time induced by barbital in rats. At identical time intervals after rats were injected with barbital the concentration of barbital in the blood or brain of animals that had previously received disulfiram was significantly higher than the concentrations in the corresponding tissues of control animals. Urinary excretion of barbital was significantly reduced in disulfiram-treated animals.This publication has 8 references indexed in Scilit:
- Impairment of hepatic microsomal drug metabolism in the rat during daily disulfiram administrationBiochemical Pharmacology, 1976
- Impairment of hepatic microsomal and plasma esterases of the rat by disulfiram and diethyldithiocarbamateBiochemical Pharmacology, 1976
- Interaction of Sodium Warfarin and Disulfiram (Antabuse®) in ManAnnals of Internal Medicine, 1973
- Impairment of drug metabolism by disulfiram in manClinical Pharmacology & Therapeutics, 1971
- The Influence of Disulfiram and Calcium Carbimide on the Serum DiphenylhydantoinArchives of Neurology, 1967
- Phenytoin Intoxication during Treatment with Antabuse® (Disulfiram)Epilepsia, 1966